Supplementation of Creatine and Ribose Prevents Apoptosis in Ischemic Cardiomyocytes

@article{Caretti2010SupplementationOC,
  title={Supplementation of Creatine and Ribose Prevents Apoptosis in Ischemic Cardiomyocytes},
  author={Anna Caretti and Paola Bianciardi and Giusy Sala and Carlo Terruzzi and Franco Lucchina and Michele Samaja},
  journal={Cellular Physiology and Biochemistry},
  year={2010},
  volume={26},
  pages={831 - 838}
}
Background/Aims. To alleviate ischemia-induced injury in the myocardium, a tissue that depends critically on energy-yielding processes, creatine may be used to enhance energy metabolism, whereas D-ribose may provide building blocks for ATP synthesis. We test the hypothesis that simultaneous supplementation of creatine+D-ribose protects non-irreversibly injured ischemic cardiomyocytes by reducing apoptosis. Results. When H9c2 cardiomyocytes were exposed to 24-h ischemia (1% O2 with glucose… 

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