Supplementation of Creatine and Ribose Prevents Apoptosis in Ischemic Cardiomyocytes

  title={Supplementation of Creatine and Ribose Prevents Apoptosis in Ischemic Cardiomyocytes},
  author={A. Caretti and P. Bianciardi and G. Sala and Carlo Terruzzi and Franco Lucchina and M. Samaja},
  journal={Cellular Physiology and Biochemistry},
  pages={831 - 838}
  • A. Caretti, P. Bianciardi, +3 authors M. Samaja
  • Published 2010
  • Biology, Medicine
  • Cellular Physiology and Biochemistry
  • Background/Aims. To alleviate ischemia-induced injury in the myocardium, a tissue that depends critically on energy-yielding processes, creatine may be used to enhance energy metabolism, whereas D-ribose may provide building blocks for ATP synthesis. We test the hypothesis that simultaneous supplementation of creatine+D-ribose protects non-irreversibly injured ischemic cardiomyocytes by reducing apoptosis. Results. When H9c2 cardiomyocytes were exposed to 24-h ischemia (1% O2 with glucose… CONTINUE READING
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