• Corpus ID: 44020647

Supplemental niacinamide mitigates anxiety symptoms: Three case reports.

@article{Prousky2005SupplementalNM,
  title={Supplemental niacinamide mitigates anxiety symptoms: Three case reports.},
  author={Jonathan E. Prousky},
  journal={Journal of Orthomolecular Medicine},
  year={2005}
}

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TLDR
Evidence is obtained that the spectrum of the activity of nicotinamide and its analogs differ from that of the classic anticonvulsants and antiepileptic drugs of the diphenin and phenobarbital series, resembling, to a greater degree, benzodiazepine tranquilizers with the predominant influence on the GABA-ergic system.
Orthomolecular Psychiatry
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Biochemical and genetic arguments support the idea that orthomolecular therapy, the provision for the individual person of the optimum concentrations of important normal constituents of the brain, may be the preferred treatment for many mentally ill patients.
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TLDR
The following case demonstrates that nicotinamide may cause major hepatic injury and is associated with abnormalities of liver function when used in large doses in the treatment of hypercholesterolemia.
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The combination of homelessness, alcohol abuse, and failure to eat regularly--particularly, failure to make use of shelter-based meal programs--may identify people at special risk in contemporary settings.
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TLDR
This case raises many questions about pellagra in the 21st century and suggests that perhaps the quote, "if you keep peLLagra in mind, you will recognize it when you see it" is not sufficient and pellagara is frequently invisible.
[The search for new anticonvulsant agents based on nicotinamide].
TLDR
Evidence is obtained that the spectrum of the activity of nicotinamide and its analogs differ from that of the classic anticonvulsants and antiepileptic drugs of the diphenin and phenobarbital series, resembling, to a greater degree, benzodiazepine tranquilizers with the predominant influence on the GABA-ergic system.
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