Supplemental Information Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase

@inproceedings{Hellwig2012SupplementalIS,
  title={Supplemental Information Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase},
  author={Sabine Hellwig and Chandra V. Miduturu and Shigeru Kanda and Jianming Zhang and Panagis Filippakopoulos and Eidarus Salah and Xianming Deng and Hwan Geun Choi and Wenjun Zhou and Wooyoung Hur and Stefan Knapp and Nathanael S Gray and Thomas E Smithgall},
  year={2012}
}
Figure S1: Identification of Fes inhibitors using the Z-LYTETM in vitro kinase assay and a recombinant Fes SH2-kinase domain (SH2-KD) protein. Provides overview of “hit” distribution in the compound library used in the FRET-based screen. Relates to Figure 1. Figure S2: Concentration-response curves for Fes kinase inhibitor candidates. Shows chemical structures of compounds identified in the primary inhibitor screen and 10-point titration curves that gave rise to IC50 values listed in Table 1… CONTINUE READING