Supplement 1 : Ensuring the Functionalities of Retrogenes


We defined retrogene as an “intact” retrocopy that has transcriptional evidence (see Results section). It is possible that some retrocopies are mis-annotated as retrogenes and included in our dataset. So, at first, we checked that all DNA sequences of candidate retrogenes have no frameshift mutations and no premature stop codons as compared to its parental… (More)

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