Supine cycling plus volume loading prevent cardiovascular deconditioning during bed rest.

  title={Supine cycling plus volume loading prevent cardiovascular deconditioning during bed rest.},
  author={Shigeki Shibata and Merja Perhonen and Benjamin D Levine},
  journal={Journal of applied physiology},
  volume={108 5},
There are two possible mechanisms contributing to the excessive fall of stroke volume (and its contribution to orthostatic intolerance) in the upright position after bed rest or spaceflight: reduced cardiac filling due to hypovolemia and/or a less distensible heart due to cardiac atrophy. We hypothesized that preservation of cardiac mechanical function by exercise training, plus normalization of cardiac filling with volume infusion, would prevent orthostatic intolerance after bed rest. Eighteen… CONTINUE READING


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