Supervised normalization of microarrays

  title={Supervised normalization of microarrays},
  author={Brigham H. Mecham and Peter S. Nelson and John D. Storey},
MOTIVATION A major challenge in utilizing microarray technologies to measure nucleic acid abundances is 'normalization', the goal of which is to separate biologically meaningful signal from other confounding sources of signal, often due to unavoidable technical factors. It is intuitively clear that true biological signal and confounding factors need to be simultaneously considered when performing normalization. However, the most popular normalization approaches do not utilize what is known… CONTINUE READING


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