Supersensitivity to norepinephrine in chronically denervated kidneys: evidence for a postsynaptic effect.

@article{Krayacich1987SupersensitivityTN,
  title={Supersensitivity to norepinephrine in chronically denervated kidneys: evidence for a postsynaptic effect.},
  author={J Krayacich and Robert L Kline and Paul Mercer},
  journal={Canadian journal of physiology and pharmacology},
  year={1987},
  volume={65 11},
  pages={2219-24}
}
Denervation supersensitivity in chronically denervated kidneys increases renal responsiveness to increased plasma levels of norepinephrine. To determine whether this effect is caused by presynaptic (i.e., loss of uptake) or postsynaptic changes, we studied the effect of continuous infusion of norepinephrine (330 ng/min, i.v.) and methoxamine (4 micrograms… CONTINUE READING