Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase.

@article{Cravatt2001SupersensitivityTA,
  title={Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase.},
  author={Benjamin F Cravatt and Kristin Demarest and Matthew P. Patricelli and Michael H Bracey and Dan K. Giang and Billy R. Martin and Aron H. Lichtman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 16},
  pages={9371-6}
}
The medicinal properties of marijuana have been recognized for centuries, but clinical and societal acceptance of this drug of abuse as a potential therapeutic agent remains fiercely debated. An attractive alternative to marijuana-based therapeutics would be to target the molecular pathways that mediate the effects of this drug. To date, these neural signaling pathways have been shown to comprise a cannabinoid receptor (CB(1)) that binds the active constituent of marijuana, tetrahydrocannabinol… CONTINUE READING
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