Corpus ID: 76658458

Supersensitivity of 5-HT 1 A-autoreceptors and α 2-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats

  title={Supersensitivity of 5-HT 1 A-autoreceptors and $\alpha$ 2-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats},
  author={A. Sastre-Coll and S. Esteban}
Chronic treatment and withdrawal of the cannabinoid agonist WIN 55,212-2 modulate the sensitivity of presynaptic receptors involved in the regulation of monoamine syntheses in rat brain
Brain monoamines are involved in many neurochemical and behavioral effects of cannabinoids, but little is known on the regulation of noradrenaline, dopamine, and serotonin (5-HT) synthesis inExpand
Preliminary evidence of different and clinically meaningful opioid withdrawal phenotypes
Patients have meaningfully different experiences of opioid withdrawal that may predict differential response to opioid pharmacotherapies during supervised withdrawal, and additional prospective research to replicate and more thoroughly evaluate withdrawal phenotype correlates and sex differences is warranted. Expand
Duloxetine attenuated morphine withdrawal syndrome in the rat.
Results indicate that the regulatory effects on serotonergic and noradrenergic parameters might be associated with the amelioration of the withdrawal symptoms. Expand
[Serotoninergic antidepressants and opiate analgesics: a sometimes-painful association. A case report].
Clinicians and especially psychiatrists should be aware of possible interaction and the risk of serotonin syndrome when a patient receives a combination of different opioid analgesics and serotonin reuptake inhibitor antidepressants. Expand
Changes in c-fos expression in the rat heart during morphine withdrawal. Involvement of α2-adrenoceptors
The results suggest that noradrenergic neurons in the heart are active during morphine withdrawal, and that activation of transcriptional responses mediated by Fos are dependent upon cardiac α2-adrenoceptor. Expand
Chronic Morphine Treatment Inhibits Opioid Receptor Desensitization and Internalization
It is demonstrated that chronic morphine treatment produces adaptational changes at the β-arrestin1 level, which in turn attenuates agonist-mediated desensitization and internalization of G-protein-coupled receptors. Expand