Supersensitive presynaptic dopamine D2 receptor inhibition of the striatopallidal projection in nigrostriatal dopamine-deficient mice.

@article{Wei2013SupersensitivePD,
  title={Supersensitive presynaptic dopamine D2 receptor inhibition of the striatopallidal projection in nigrostriatal dopamine-deficient mice.},
  author={Wei Wei and Li Li and Guoliang Yu and Shengyuan Ding and Cheng Li and Fu-Ming Zhou},
  journal={Journal of neurophysiology},
  year={2013},
  volume={110 9},
  pages={
          2203-16
        }
}
The dopamine (DA) D2 receptor (D2R)-expressing medium spiny neurons (D2-MSNs) in the striatum project to and inhibit the GABAergic neurons in the globus pallidus (GP), forming an important link in the indirect pathway of the basal ganglia movement control circuit. These striatopallidal axon terminals express presynaptic D2Rs that inhibit GABA release and thus regulate basal ganglion function. Here we show that in transcription factor Pitx3 gene mutant mice with a severe DA loss in the dorsal… 

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