Supersaturation of Calcipotriene and Betamethasone Dipropionate in a Novel Aerosol Foam Formulation for Topical Treatment of Psoriasis Provides Enhanced Bioavailability of the Active Ingredients

@inproceedings{Lind2016SupersaturationOC,
  title={Supersaturation of Calcipotriene and Betamethasone Dipropionate in a Novel Aerosol Foam Formulation for Topical Treatment of Psoriasis Provides Enhanced Bioavailability of the Active Ingredients},
  author={Marianne Lind and Kim Troensegaard Nielsen and Line Hollesen Schefe and Kasper N\orremark and Andr{\'e} Huss Eriksson and Hanne Norsgaard and Brian Thoning Pedersen and Karsten Petersson},
  booktitle={Dermatology and therapy},
  year={2016}
}
INTRODUCTION Previous studies have demonstrated the superior efficacy of a novel aerosol foam formulation of fixed combination calcipotriene 0.005% (Cal) and betamethasone dipropionate 0.064% (BD), compared with the ointment formulation. The aim of this study is to ascertain whether enhanced bioavailability of the active ingredients due to supersaturation and/or occlusive properties can explain the observed greater clinical efficacy. METHODS Solubility and evaporation experiments were… CONTINUE READING
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