Supersaturatable formulations for the enhanced oral absorption of sirolimus.

  title={Supersaturatable formulations for the enhanced oral absorption of sirolimus.},
  author={Min-Soo Kim and Jeong-Soo Kim and Wonkyung Cho and Kwang-ho Cha and Hee-Jun Park and Junsung Park and Sung-Joo Hwang},
  journal={International journal of pharmaceutics},
  volume={445 1-2},
The purpose of this study was to develop supersaturatable formulations for the enhanced solubility and oral absorption of sirolimus. Supersaturatable formulations of hydrophilic polymers and/or surfactants were screened by formulation screening, which is based on solvent casting. The solid dispersion particles in the optimized formulations were prepared by spray drying. The particles were characterized in vitro and in vivo. The most effective supersaturatable formulation found in the… CONTINUE READING


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