Superresolution microscopy reveals spatial separation of UCP4 and F0F1-ATP synthase in neuronal mitochondria.

  title={Superresolution microscopy reveals spatial separation of UCP4 and F0F1-ATP synthase in neuronal mitochondria.},
  author={Enrico Klotzsch and Alina Smorodchenko and Lukas L{\"o}fler and Rudolf Moldzio and Elena Parkinson and Gerhard J Sch{\"u}tz and Elena E. Pohl},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 1},
Because different proteins compete for the proton gradient across the inner mitochondrial membrane, an efficient mechanism is required for allocation of associated chemical potential to the distinct demands, such as ATP production, thermogenesis, regulation of reactive oxygen species (ROS), etc. Here, we used the superresolution technique dSTORM (direct stochastic optical reconstruction microscopy) to visualize several mitochondrial proteins in primary mouse neurons and test the hypothesis that… CONTINUE READING
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