Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury.

  title={Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury.},
  author={Johannes Riegler and Aaron Liew and Sean O Hynes and Daniel Mart{\'i} i Ortega and Timothy O'Brien and Richard M. Day and Toby Richards and Faisal Sharif and Quentin A. Pankhurst and Mark F. Lythgoe},
  volume={34 8},
Vascular occlusion can result in fatal myocardial infarction, stroke or loss of limb in peripheral arterial disease. Interventional balloon angioplasty is a common first line procedure for vascular disease treatment, but long term success is limited by restenosis and neointimal hyperplasia. Cellular therapies have been proposed to mitigate these issues; however efficacy is low, in part due to poor cell retention. We show that magnetic targeting of mesenchymal stem cells gives rise to a 6-fold… CONTINUE READING
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