Superparamagnetic iron oxide enhanced magnetic resonance imaging of rat liver with hepatocellular carcinoma and benign hyperplastic nodule.

@article{Ishida1997SuperparamagneticIO,
  title={Superparamagnetic iron oxide enhanced magnetic resonance imaging of rat liver with hepatocellular carcinoma and benign hyperplastic nodule.},
  author={Takeshi Ishida and Takamichi Murakami and Naoki Kato and Masaya Takahashi and Tomoaki Miyazawa and Kyo Tsuda and Kaname Tomoda and Yoshifumi Narumi and Hironobu Nakamura},
  journal={Investigative radiology},
  year={1997},
  volume={32 5},
  pages={282-7}
}
RATIONALE AND OBJECTIVES The authors assess the potential of a new superparamagnetic iron oxide (SPIO) in grading hepatocellular carcinoma (HCC) histologically and in differentiating HCC from benign hyperplastic nodule (HPN). METHODS Nine Wistar rats (with poorly to moderately differentiated HCC, well-differentiated HCC, and HPN) received drinking water containing N-nitrosomorpholine, and were examined by magnetic resonance imaging (4.7 tesla). Spin-echo images (repetition time/echo time, 600… CONTINUE READING