Superparamagnetic Iron Oxide Nanoparticles Labeling of Bone Marrow Stromal (Mesenchymal) Cells Does Not Affect Their “Stemness”

@inproceedings{Balakumaran2010SuperparamagneticIO,
  title={Superparamagnetic Iron Oxide Nanoparticles Labeling of Bone Marrow Stromal (Mesenchymal) Cells Does Not Affect Their “Stemness”},
  author={Arun Balakumaran and Edyta Pawelczyk and Jiaqiang Ren and Brian J Sworder and Aneeka G Chaudhry and Marianna Sabatino and David E Stroncek and Joseph A. Frank and Pamela Robey},
  booktitle={PloS one},
  year={2010}
}
Superparamagnetic iron oxide nanoparticles (SPION) are increasingly used to label human bone marrow stromal cells (BMSCs, also called "mesenchymal stem cells") to monitor their fate by in vivo MRI, and by histology after Prussian blue (PB) staining. SPION-labeling appears to be safe as assessed by in vitro differentiation of BMSCs, however, we chose to resolve the question of the effect of labeling on maintaining the "stemness" of cells within the BMSC population in vivo. Assays performed… CONTINUE READING