Superparamagnetic Iron Oxide Nanoparticles: Amplifying ROS Stress to Improve Anticancer Drug Efficacy

@inproceedings{Huang2013SuperparamagneticIO,
  title={Superparamagnetic Iron Oxide Nanoparticles: Amplifying ROS Stress to Improve Anticancer Drug Efficacy},
  author={Gang Huang and Huabing Chen and Ying Dong and Xiuquan Luo and Yaping Li and Zachary R. Moore and Erik A. Bey and David A. Boothman and Jinming Gao},
  booktitle={Theranostics},
  year={2013}
}
Superparamagnetic iron oxide nanoparticles (SPION) are an important and versatile nano- platform with broad biological applications. Despite extensive studies, the biological and pharmacological activities of SPION have not been exploited in therapeutic applications. Recently, β-lapachone (β-lap), a novel anticancer drug, has shown considerable cancer specificity by selectively increasing reactive oxygen species (ROS) stress in cancer cells. In this study, we report that pH-responsive SPION… CONTINUE READING