Superoxide stimulates NaCl absorption by the thick ascending limb.

@article{Ortiz2002SuperoxideSN,
  title={Superoxide stimulates NaCl absorption by the thick ascending limb.},
  author={Pablo Alfredo Ortiz and Jeffrey L. Garvin},
  journal={American journal of physiology. Renal physiology},
  year={2002},
  volume={283 5},
  pages={F957-62}
}
The thick ascending limb of the loop of Henle (THAL) plays an important role in the regulation of NaCl and water reabsorption. In vivo studies have shown that the free radical superoxide (O) stimulates Na and water reabsorption by the kidney. However, it is not known whether O regulates transport along the nephron in general or in the THAL specifically. We hypothesized that O stimulates THAL NaCl reabsorption. Cl absorption was measured in isolated, perfused THALs from Sprague-Dawley rats… CONTINUE READING

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