Superoxide scavenging effect of Ginkgo biloba extract on serotonin-induced mitogenesis.

  title={Superoxide scavenging effect of Ginkgo biloba extract on serotonin-induced mitogenesis.},
  author={S. L. Lee and W. Wang and J. Lanzillo and C. N. Gillis and B. Fanburg},
  journal={Biochemical pharmacology},
  volume={56 4},
  • S. L. Lee, W. Wang, +2 authors B. Fanburg
  • Published 1998
  • Biology, Medicine
  • Biochemical pharmacology
  • We have reported previously that serotonin (5-HT) stimulates the mitogenesis of bovine pulmonary artery smooth muscle cells (SMCs) through active transport of 5-HT and cellular signaling that includes elevation of superoxide (O2.-) and enhancement of protein tyrosine phosphorylation. Ginkgo biloba extract 501 (EGb 501), which has been demonstrated to act as an antioxidant, was found to block both the elevated O2.- and the proliferative and hypertrophic influences of 5-HT on SMCs, but not to… CONTINUE READING
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