Superoxide-mediated clastogenesis and anticlastogenic effects of exogenous superoxide dismutase.

  title={Superoxide-mediated clastogenesis and anticlastogenic effects of exogenous superoxide dismutase.},
  author={Ingrid Emerit and Fr{\'e}d{\'e}ric Garban and Jany Vassy and Andy Levy and Paulo Filipe and Jo{\~a}o Freitas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 23},
Superoxide-mediated clastogenesis is characteristic for various chronic inflammatory diseases with autoimmune reactions and probably plays a role in radiation-induced clastogenesis and in the congenital breakage syndromes. It is consistently prevented by exogenous superoxide dismutase (SOD), but not by heat-inactivated SOD, indicating that the anticlastogenic effect is related to the catalytic function of the enzyme. Increased superoxide production by activated monocytes/macrophages is followed… CONTINUE READING
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Emerit et al

  • Flohé, 84 L.Mol.Cell.Biochem., 123–131. 12804 Biochemistry
  • Proc. Natl. Acad. Sci. USA 93
  • 1996
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