Superoxide is produced by the reduced flavin in mitochondrial complex I: a single, unified mechanism that applies during both forward and reverse electron transfer.

Abstract

NADH:ubiquinone oxidoreductase (complex I) is a major source of reactive oxygen species in mitochondria and a contributor to cellular oxidative stress. In isolated complex I the reduced flavin is known to react with molecular oxygen to form predominantly superoxide, but studies using intact mitochondria contend that superoxide may result from a semiquinone… (More)
DOI: 10.1074/jbc.M110.186841

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@article{Pryde2011SuperoxideIP, title={Superoxide is produced by the reduced flavin in mitochondrial complex I: a single, unified mechanism that applies during both forward and reverse electron transfer.}, author={Kenneth Robert Pryde and Judy Hirst}, journal={The Journal of biological chemistry}, year={2011}, volume={286 20}, pages={18056-65} }