Superoxide-induced potentiation in the hippocampus requires activation of ryanodine receptor type 3 and ERK.

@article{Huddleston2008SuperoxideinducedPI,
  title={Superoxide-induced potentiation in the hippocampus requires activation of ryanodine receptor type 3 and ERK.},
  author={A. Tara Huddleston and Wei Tang and Hiroshi Takeshima and Susan L. Hamilton and Eric Klann},
  journal={Journal of neurophysiology},
  year={2008},
  volume={99 3},
  pages={1565-71}
}
Reactive oxygen species (ROS) are required for the induction of long-term potentiation (LTP) and behave as signaling molecules via redox modifications of target proteins. In particular, superoxide is necessary for induction of LTP, and application of superoxide to hippocampal slices is sufficient to induce LTP in area CA1. Although a rise in postsynaptic intracellular calcium is necessary for LTP induction, superoxide-induced potentiation does not require calcium flux through N-methyl-d… CONTINUE READING