Superoxide-hydrogen peroxide genetic imbalance modulates differentially the oxidative metabolism on human peripheral blood mononuclear cells exposed to seleno-L-methionine.

@article{Schott2017SuperoxidehydrogenPG,
  title={Superoxide-hydrogen peroxide genetic imbalance modulates differentially the oxidative metabolism on human peripheral blood mononuclear cells exposed to seleno-L-methionine.},
  author={Karen Lilian Schott and Charles Elias Assmann and Fernanda Barbisan and Ver{\^o}nica Farina Azzolin and Beatriz da Silva Rosa Bonadiman and Marta Maria Medeiros Frescura Duarte and Alencar Kolinski Machado and Ivana Beatrice M{\^a}nica da Cruz},
  journal={Chemico-biological interactions},
  year={2017},
  volume={273},
  pages={18-27}
}
Superoxide-hydrogen peroxide (S-HP) imbalance genetically caused by a gene polymorphism in the human manganese superoxide dismutase enzyme (Val16Ala-MnSOD) is associated with several diseases. Into mitochondria, MnSOD catalyses superoxide radical producing HP and oxygen. Ala-MnSOD genotype presents a high MnSOD efficiency and generates the highest HP… CONTINUE READING