Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling.

@article{Hawkins2007SuperoxideFI,
  title={Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling.},
  author={Brian J. Hawkins and Muniswamy Madesh and C James Kirkpatrick and Aron B. Fisher},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 6},
  pages={
          2002-12
        }
}
Reactive oxygen species (ROS) have been implicated in both cell signaling and pathology. A major source of ROS in endothelial cells is NADPH oxidase, which generates superoxide (O(2)(.-)) on the extracellular side of the plasma membrane but can result in intracellular signaling. To study possible transmembrane flux of O(2)(.-), pulmonary microvascular endothelial cells were preloaded with the O(2)(.-)-sensitive fluorophore hydroethidine (HE). Application of an extracellular bolus of O(2… CONTINUE READING
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Superoxide Flux Page 30 of 34 January

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Superoxide Flux Page 31 of 34 January 5, 2007 Figure 2. HE oxidation transient in a cell-free system. (A) Fluorescence change

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the electron transport chain causes O2-. -mediated mitochondrial outgrowth

  • H. M. Korchak, B. A. Eisenstat, S. T. Hoffstein, P. B. Dunham, G. Weissmann
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