Superoxide enhances tubuloglomerular feedback by constricting the afferent arteriole.

@article{Liu2004SuperoxideET,
  title={Superoxide enhances tubuloglomerular feedback by constricting the afferent arteriole.},
  author={Ruisheng Liu and Yilin Ren and Jeffrey L. Garvin and Oscar A. Carretero},
  journal={Kidney international},
  year={2004},
  volume={66 1},
  pages={268-74}
}
BACKGROUND Superoxide (O(2) (-)) has been shown to augment tubuloglomerular feedback (TGF) both in vivo and in vitro by scavenging nitric oxide (NO) in the macula densa (MD). We hypothesized that in addition to this mechanism O(2) (-) potentiates TGF by acting directly on the afferent arteriole (Af-Art). METHODS Microdissected Af-Arts and adherent tubular segments containing the MD were simultaneously microperfused in vitro, maintaining Af-Art pressure at 60 mm Hg. TGF response was determined… CONTINUE READING
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