Superoxide enhances the spread of HIV-1 infection by cell-to-cell transmission.


Oxidative stress is thought to be involved in the progression of human immunodeficiency virus type 1 (HIV-1)-induced disease. We examined the effect of superoxide (O2-) on HIV-1 spread in cultured human CD4+ cell lines. The O2- significantly enhanced cell-to-cell transmission of HIV-1, although its effect on HIV-1 replication was not evident, presumably due… (More)


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