Superoxide dismutases in relation to the overall survival of colorectal cancer patients.

  title={Superoxide dismutases in relation to the overall survival of colorectal cancer patients.},
  author={A Miranda L Janssen and C. B. Bosman and Cornelis Fm Sier and Gerrit Griffioen and Frank J. G. M. Kubben and Cornelis B. H. W. Lamers and Johan Hjm van Krieken and Cornelis J. H. van de Velde and Hein W. Verspaget},
  journal={British Journal of Cancer},
  pages={1051 - 1057}
Reactive oxygen metabolites are implicated in the initiation and promotion of cancer. In addition, oxidant scavengers, such as manganese--(Mn-SOD) and copper/zinc--superoxide dismutase (Cu/Zn-SOD), are thought to contribute to colorectal cancer treatment response. In the present study, the prognostic significance of the Mn- and Cu/Zn-SOD antigen content of normal mucosa and carcinomas of 163 patients with colorectal cancer was evaluated in comparison with major clinicopathological parameters… CONTINUE READING
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