Superoxide dismutases in malignant cells and human tumors.

  title={Superoxide dismutases in malignant cells and human tumors.},
  author={Vuokko L. Kinnula and James D. Crapo},
  journal={Free radical biology & medicine},
  volume={36 6},
Reactive oxygen metabolites have multifactorial effects on the regulation of cell growth and the capacity of malignant cells to invade. Overexpression of the superoxide dismutases (SODs) in vitro increases cell differentiation, decreases cell growth and proliferation, and can reverse a malignant phenotype to a nonmalignant one. The situation in vivo is more complex due to multiple interactions of tumor cells with their environment. Numerous in vivo studies show that the superoxide dismutases… CONTINUE READING
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