Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans.

@article{Keaney2004SuperoxideDM,
  title={Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans.},
  author={Michelle Keaney and Filip Matthijssens and Martyn A Sharpe and Jacques R. Vanfleteren and David Gems},
  journal={Free radical biology & medicine},
  year={2004},
  volume={37 2},
  pages={239-50}
}
According to the oxidative damage theory a primary cause of aging is the accrual of molecular damage from reactive oxygen species (ROS), particularly superoxide and its derivatives. This predicts that treatments that reduce ROS levels should retard aging. Using the nematode Caenorhabditis elegans, we tested the effects on stress resistance and life span of treatment with EUK-8 and EUK-134, synthetic mimetics of the antioxidant enzyme superoxide dismutase (SOD), which neutralises superoxide… CONTINUE READING

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