Superoxide dismutase mimetic drug tempol aggravates anti-GBM antibody-induced glomerulonephritis in mice.

  title={Superoxide dismutase mimetic drug tempol aggravates anti-GBM antibody-induced glomerulonephritis in mice.},
  author={Hua Lu and Junhui Zhen and Tianfu Wu and Ai Peng and Ting Ye and Tao Wang and Xueqing Yu and Nosratola D. Vaziri and Chandra Mohan and Xin J Zhou},
  journal={American journal of physiology. Renal physiology},
  volume={299 2},
  • Hua LuJ. Zhen Xin J Zhou
  • Published 1 August 2010
  • Biology, Medicine
  • American journal of physiology. Renal physiology
Oxidative stress plays an important role in the pathogenesis of anti-glomerular basement membrane antibody-induced glomerulonephritis (anti-GBM-GN). Superoxide dismutase (SOD) is the first line of defense against oxidative stress by converting superoxide to hydrogen peroxide (H(2)O(2)). We investigated the effect of the SOD mimetic drug tempol on anti-GBM-GN in mice. 129/svJ mice were challenged with rabbit anti-mouse-GBM sera to induce GN and subsequently divided into tempol (200… 

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