Superoxide dismutase gene transfer reduces portal pressure in CCl4 cirrhotic rats with portal hypertension.

@article{Lavia2009SuperoxideDG,
  title={Superoxide dismutase gene transfer reduces portal pressure in CCl4 cirrhotic rats with portal hypertension.},
  author={B{\`a}rbara Lavi{\~n}a and Jorge Gracia-Sancho and Aina Rodr{\'i}guez-Vilarrupla and Y Chu and Donald D. Heistad and J Bosch and Juan Carlos Garc{\'i}a-Pag{\'a}n},
  journal={Gut},
  year={2009},
  volume={58 1},
  pages={118-25}
}
BACKGROUND Increased intrahepatic vascular tone in cirrhosis has been attributed to a decrease of hepatic nitric oxide (NO) secondary to disturbances in the post-translational regulation of the enzyme eNOS. NO scavenging by superoxide (O(2)(-)) further contributes to a reduction of NO bioavailability in cirrhotic livers. AIM To investigate whether removing increased O(2)(-) levels could be a new therapeutic strategy to increase intrahepatic NO, improve endothelial dysfunction and reduce… CONTINUE READING

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