Superoxide dismutase and catalase activity in psoriatic patients treated topically with ointment containing 2-chloroethyl-3-chloropropyl sulfide.
@article{Kopff1994SuperoxideDA, title={Superoxide dismutase and catalase activity in psoriatic patients treated topically with ointment containing 2-chloroethyl-3-chloropropyl sulfide.}, author={Maria Kopff and I Zakrzewska and Małgorzata Strzelczyk and Jennifer Klem and W Dubiecki}, journal={Polish journal of pharmacology}, year={1994}, volume={46 5}, pages={ 439-44 } }
The purpose of this study was to determine dismutase and catalase activities in erythrocytes of psoriatic patients with psoriasis vulgaris topically treated with an ointment (in accordance with recommendations of the Helsinki Declaration), in which 2-chloroethyl-3-chloropropyl sulfide (CLEPS) is an active compound. SOD activity in hemolysates was determined according to the method of Misra and Fridovich [12] and calculated as units per g of hemoglobin. CAT activity in hemolysates was determined…
12 Citations
Antioxidant potential of propylthiouracil in patients with psoriasis.
- Medicine, BiologyClinical biochemistry
- 2002
Activity and function in lung injuries due to sulphur mustard
- Medicine, Biology
- 2008
It is reasonable to hypothesize that re-establishment of the activation–inactivation or oxidant–antioxidant balance in favour of theactivation and antioxidant balances would be useful as a therapeutic strategy to suppress pathological mechanisms underlying lung injuries.
Modulation of the expression of superoxide dismutase gene in lung injury by 2‐chloroethyl ethyl sulfide, a mustard analog
- BiologyJournal of biochemical and molecular toxicology
- 2006
The results indicate that the overall decrease in the activity of SOD is probably mediated by direct inactivation of the SOD‐3 gene or the enzyme itself, and may be due to the cleavage of active form of the protein to an inactive form.
Inhibition of cholinephosphotransferase activity in lung injury induced by 2‐chloroethyl ethyl sulfide, a mustard analog
- BiologyJournal of biochemical and molecular toxicology
- 2005
It is indicated that CEES causes lung injury and significantly decreases CPT gene expression and activity and may play an important role in the development of ARDS by modulating CPT enzyme.
The systemic nature of mustard lung: Comparison with COPD patients
- Medicine, BiologyInterdisciplinary toxicology
- 2017
The comparative study of changes in the mentioned markers in mustard lung and COPD patients at stable phases and the mechanisms of pathogenesis and phenomena, such as airway remodeling in these patients are followed.
Ability of antioxidant liposomes to prevent acute and progressive pulmonary injury.
- Medicine, BiologyAntioxidants & redox signaling
- 2008
The data demonstrate that delivery of antioxidants via liposomes to CEES-injured lungs is, depending on liposomal content, protective against ALI, prevents the appearance of proinflammatory mediators in bronchoalveolar fluids, and suppresses progressive fibrosis.
Signal transduction events in lung injury induced by 2‐chloroethyl ethyl sulfide, a mustard analog
- BiologyJournal of biochemical and molecular toxicology
- 2003
It is shown that guinea pigs exposed to CEES intratracheally accumulate high levels of TNF‐α, which leads to activation of both acid and neutral sphingomyelinases, resulting in high accumulation of ceramides, a second messenger involved in cell apoptosis.
Activation of MAPK/AP-1 signaling pathway in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard gas analog.
- BiologyToxicology letters
- 2008
Extra cellular Superoxide Dismutase activity in lung injuries due to Sulfur Mustard
- Biology, Medicine
- 2009
Inactivation of EC-SOD may lead to progressive inflammation and lung injury due to sulfur mustard, and significant and direct association between EC- SOD activities and lung function was established.
The Mustard Consortium's Elucidation of the Pathophysiology of Sulfur Mustard and Antidote Development
- Biology
- 2006
The Mustards Consortium has utilized both in vivo and in vitro models simultaneously to continue to elucidate mustard gas pathophysiology and a combination of a water and fat soluble antioxidant encapsulated in a liposome (STIMAL) was found to have the best ameliorative effect against CEES.