Superoxide dismutase ameliorates TNBS‐induced colitis by reducing oxidative stress, adhesion molecule expression, and leukocyte recruitment into the inflamed intestine

@article{Segu2004SuperoxideDA,
  title={Superoxide dismutase ameliorates TNBS‐induced colitis by reducing oxidative stress, adhesion molecule expression, and leukocyte recruitment into the inflamed intestine},
  author={Joaquim Segu{\'i} and Meritxell Gironella and Miquel Sans and Susana Granell and F{\'e}lix Gil and Mercedes Gimeno and Pilar Coronel and Josep Mar{\'i}a Piqu{\'e} and Juli{\'a}n Pan{\'e}s},
  journal={Journal of Leukocyte Biology},
  year={2004},
  volume={76}
}
Oxidant stress has been implicated in the pathogenesis of inflammatory bowel disease. Antioxidant enzymes, such as superoxide dismutase (SOD), are candidate drugs for modulating this pathogenic factor. This study was designed to determine the therapeutic value of SOD in an experimental model of colitis and to study the mechanisms underlying its effects on intestinal inflammation. For that purpose, colitic (trinitrobenzene sulfonic acid‐induced) and control rats were studied. Groups of colitic… Expand
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