Superoxide dismutase ameliorates TNBS‐induced colitis by reducing oxidative stress, adhesion molecule expression, and leukocyte recruitment into the inflamed intestine

@article{Segu2004SuperoxideDA,
  title={Superoxide dismutase ameliorates TNBS‐induced colitis by reducing oxidative stress, adhesion molecule expression, and leukocyte recruitment into the inflamed intestine},
  author={Joaquim Segu{\'i} and Meritxell Gironella and Miquel Sans and Susana Granell and F{\'e}lix Gil and Mercedes Gimeno and Pilar Coronel and Josep Mar{\'i}a Piqu{\'e} and Juli{\'a}n Pan{\'e}s},
  journal={Journal of Leukocyte Biology},
  year={2004},
  volume={76}
}
Oxidant stress has been implicated in the pathogenesis of inflammatory bowel disease. Antioxidant enzymes, such as superoxide dismutase (SOD), are candidate drugs for modulating this pathogenic factor. This study was designed to determine the therapeutic value of SOD in an experimental model of colitis and to study the mechanisms underlying its effects on intestinal inflammation. For that purpose, colitic (trinitrobenzene sulfonic acid‐induced) and control rats were studied. Groups of colitic… 
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168 Citations

Resveratrol abrogates adhesion molecules and protects against TNBS-induced ulcerative colitis in rats.
TLDR
The study confirms the anti-ulcerative effect of resveratrol in TNBS-induced experimental colitis via reduction of neutrophil infiltration, inhibition of adhesive molecules, and restoration of the nitric oxide level, as well as the redox status.
Anti-inflammatory properties of Lactobacillus gasseri expressing manganese superoxide dismutase using the interleukin 10-deficient mouse model of colitis.
TLDR
This study demonstrates that L. gasseri producing MnSOD has significant anti-inflammatory activity that reduces the severity of colitis in the IL-10-deficient mouse.
Inhibition of Tumor Necrosis Factor and Nitrosative/Oxidative Stresses by Ziziphora Clinopoides (Kahlioti); A Molecular Mechanism of Protection Against Dextran Sodium Sulfate-Induced Colitis in Mice
TLDR
The present study further supports the role of oxidative/nitrosative stresses and TNF-α in the pathogenesis of colitis and protective effects of this herb and promising for further preclinical studies directed towards understanding mechanism of action andCross-species and cross-model comparisons for potential protective effects.
Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn's disease in mice.
Glutamine Treatment Attenuates Endoplasmic Reticulum Stress and Apoptosis in TNBS-Induced Colitis
TLDR
Data obtained indicated that modulation of ER stress signalling and anti-apoptotic effects contribute to protection by glutamine against damage in TNBS-induced colitis.
Therapeutic Effect of Lecithinized Superoxide Dismutase against Colitis
TLDR
It is suggested that PC-SOD achieves its ameliorative effect against colitis through decreasing the colonic level of ROS and that its ineffectiveness at higher doses is because of the accumulation of hydrogen peroxide.
3,3'-Diindolylmethane decreases VCAM-1 expression and alleviates experimental colitis via a BRCA1-dependent antioxidant pathway.
Inhalation of Carbon Monoxide Ameliorates TNBS-Induced Colitis in Mice Through the Inhibition of TNF-α Expression
TLDR
The inhalation of CO protected mice from developing intestinal inflammation and the beneficial effects of CO in a murine colitis model may be attributed to its anti-inflammatory properties.
Anti-inflammatory effects of Lactobacillus casei BL23 producing or not a manganese-dependant catalase on DSS-induced colitis in mice
BackgroundHuman immune cells generate large amounts of reactive oxygen species (ROS) throughout the respiratory burst that occurs during inflammation. In inflammatory bowel diseases, a sustained and…
Anti-inflammatory properties of Bifidobacterium longum expressing human manganese superoxide dismutase using the TNBS-induced rats model of colitis.
TLDR
The histological analysis of the colon tissue section revealed that the engineered B. longum was efficient in attenuating UC damage, suggesting that preventing UC by the use of B.Longum harboring rhMn-SOD could be an alternative choice.
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