Superoxide dismutase 3 polymorphism associated with reduced lung function in two large populations.

@article{Dahl2008SuperoxideD3,
  title={Superoxide dismutase 3 polymorphism associated with reduced lung function in two large populations.},
  author={Morten Dahl and Russell P Bowler and Klaus Juul and James D. Crapo and Samuel Levy and B\orge G. Nordestgaard},
  journal={American journal of respiratory and critical care medicine},
  year={2008},
  volume={178 9},
  pages={906-12}
}
RATIONALE Superoxide dismutase (SOD) 3 inhibits oxidative fragmentation of lung matrix components collagen I, hyaluronan, and heparan sulfate. Inherited change in SOD3 expression or function could affect lung matrix homeostasis and influence pulmonary function. OBJECTIVES To identify novel SOD3 polymorphisms that are associated with lung function or chronic obstructive pulmonary disease (COPD). METHODS Resequencing of 182 individuals identified two novel polymorphisms, E1 (rs8192287) and I1… CONTINUE READING

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