Superoxide dismutase 3 is induced by antioxidants, inhibits oxidative DNA damage and is associated with inhibition of estrogen-induced breast cancer.

@article{Singh2012SuperoxideD3,
  title={Superoxide dismutase 3 is induced by antioxidants, inhibits oxidative DNA damage and is associated with inhibition of estrogen-induced breast cancer.},
  author={Bhupendra Singh and Hari K. Bhat},
  journal={Carcinogenesis},
  year={2012},
  volume={33 12},
  pages={2601-10}
}
Epidemiological data and studies in rodent models strongly support the role of estrogens in the development of breast cancers. Oxidative stress has been implicated in this carcinogenic process. We have recently demonstrated that antioxidants vitamin C or butylated hydroxyanisole (BHA) severely inhibit 17β-estradiol (E2)-induced breast tumor development in female ACI rats. The objective of this study was to characterize the mechanism of antioxidant-mediated prevention of breast cancer. Female… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Histone Acetylation Regulates Cell-specific and Interferon-gamma Inducible EC-SOD Expression in Human Pulmonary Arteries

  • Zelko, I.N
  • Am J Respir Cell Mol Biol,
  • 2011

Molecular mechanisms of Nrf2-mediated antioxidant response

  • W Li
  • Mol Carcinog,
  • 2009

Similar Papers

Loading similar papers…