Superoxide dismutase, aging, and degenerative disease.

  title={Superoxide dismutase, aging, and degenerative disease.},
  author={Huber R. Warner},
  journal={Free radical biology & medicine},
  volume={17 3},
Over 15 years of research on correlations between superoxide dismutase (SOD) activity and aging or life span have failed to provide a consistent picture of the role of SOD in aging. While genetic manipulations that increase CuZn-SOD activity have only a slight, if any, effect on maximum life span in several species, they do increase resistance to oxidative stress. However, increasing both CuZn-SOD and catalase does significantly increase maximum life span. Decreased SOD expression in a variety… CONTINUE READING