Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment.

@article{Cheng2008SuperoxidedependentCA,
  title={Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment.},
  author={Xian Wu Cheng and Toyoaki Murohara and Masafumi Kuzuya and Hideo Izawa and Takeshi Sasaki and Koji Obata and Kohzo Nagata and Takao Nishizawa and Masakazu Kobayashi and Takashi Yamada and Weon Kim and Kohji Sato and G Shi and Kenji Okumura and Mitsuhiro Yokota},
  journal={The American journal of pathology},
  year={2008},
  volume={173 2},
  pages={358-69}
}
The elastolytic activity of cathepsins in the myocardium is implicated in hypertensive heart failure (HF). Given that reactive oxygen species are also implicated in protease activation associated with cardiac remodeling, we examined the role of the reactive oxygen species-induced cathepsin activation system in cardiac remodeling during the development of hypertensive HF. Dahl salt-sensitive hypertensive rats maintained on a high-salt diet were treated with vehicle, the cathepsin inhibitor E64d… CONTINUE READING