Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium.

  title={Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium.},
  author={Sara Kerr and Mary Julia Brosnan and M Mcintyre and John L. Reid and Anna F. Dominiczak and Carlene A. Hamilton},
  volume={33 6},
The hypothesis that the decreased nitric oxide (NO) availability observed in spontaneously hypertensive stroke-prone rats (SHRSP) is due to excess superoxide (O2-) was examined. O2- generation, measured by lucigenin chemiluminescence, was studied in 12- to 16-week male and female Wistar-Kyoto rats (WKY) and SHRSP. In addition, expression of the gene encoding endothelial NO synthase, the enzyme involved in NO generation, was investigated. O2- generation was increased in male and female SHRSP (4… CONTINUE READING


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