Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy.

@article{Bivalacqua2005SuperoxideAP,
  title={Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy.},
  author={Trinity J. Bivalacqua and Mustafa Faruk Usta and Muammer Kendirci and Leena Pradhan and X. Alvarez and Hunter C. Champion and Philip J. Kadowitz and Wayne J. G. Hellstrom},
  journal={The journal of sexual medicine},
  year={2005},
  volume={2 2},
  pages={187-97; discussion 197-8}
}
INTRODUCTION Superoxide anion may contribute to erectile dysfunction (ED) in diabetes mellitus by reducing cavernosal nitric oxide (NO) bioavailability. The purpose of this study was to determine if gene transfer of extracellular superoxide dismutase (EC-SOD) can reduce superoxide anion formation and determine if this reactive oxygen species may contribute to diabetes-related ED in an experimental model of diabetes. METHODS Three groups of animals were utilized: (1) control; (2… CONTINUE READING