Superoxide anion production by monocytes of corticosteroid-treated asthmatic patients.

  title={Superoxide anion production by monocytes of corticosteroid-treated asthmatic patients.},
  author={Maria Majori and Isabelle Vachier and Philippe P Godard and Martine Farce and Jean Bousquet and Pascal Chanez},
  journal={The European respiratory journal},
  volume={11 1},
Reactive oxygen species play an important role in promoting inflammation. Blood monocytes have been described to release higher amounts of superoxide anion in uncontrolled and untreated asthmatics. Corticosteroids are widely used in asthma, but little is known about their molecular mechanism of action. The aim of our study was to analyse the ex vivo effect of corticosteroid treatments on superoxide anion release by blood monocytes. Superoxide anion release was measured by a spectrophotometric… CONTINUE READING

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