Superoxide Production by Neutrophils of Newborns and Adults


To further elucidate the dependence of innate defense mechanisms against microorganisms on age, the superoxide anion production (ferricytochrome c reduction) of resting and stimulated (zymosan treated serum) neutrophils obtained from newborns (cord blood) and adults (venous blood) was investigated. Resting newborn neutrophils produced significantly more superoxide than adult neutrophils (p<0.05, t-test) with 8.93 + 4.01 and 5.82 ± 4.34 nmole/5 × 106 cells/30 min, respectively. There was no difference between stimulated noutrophils from newborns and adults and between resting and stimulated neutrophils from the mothers and other adults. The quotient “stimulated/resting” neutrophils was 3.7 in newborns and 6.0 in adults. The meaning of the different quotients with respect to the miorobicidal capacity of newborn neutrophils remains to be elucidated in future.

DOI: 10.1203/00006450-198510000-00230

Cite this paper

@article{Schmidt1985SuperoxidePB, title={Superoxide Production by Neutrophils of Newborns and Adults}, author={Doris H Schmidt and Harald Koeditz and J Morenz}, journal={Pediatric Research}, year={1985}, volume={19}, pages={1108-1108} }