Corpus ID: 92475794

Superoxide Generation in Directional Coronary Atherectomy Specimens of Patients With Angina Pectoris

  title={Superoxide Generation in Directional Coronary Atherectomy Specimens of Patients With Angina Pectoris},
  author={HiroshiAzumi and NobutakaInoue and YoshitakaOhashi and MitsuyasuTerashima and TakaoMori and HidekiFujita and KojiroAwano and KatsuyaKobayashi and KazumiMaeda and KatsuyaHata and ToshiroShinke and SeiichiKobayashi and Ken-ichiHirata and SeinosukeKawashima and HiroyukiItabe and YoshitakeHayashi and ShinobuImajoh-Ohmi and HiroshiItoh and MitsuhiroYokoyama},
Objective— NADH/NADPH oxidase is an important source of reactive oxygen species (ROS) in the vasculature. Recently, we demonstrated that p22phox, an essential component of this oxidase, was expressed in human coronary arteries and that its expression was enhanced with the progression of atherosclerosis. The present study was undertaken to investigate its functional importance in the pathogenesis of coronary artery disease. For this aim, the expression of p22phox, the distribution of oxidized… Expand
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