Superoxide Generation from Nitric Oxide Synthase

@inproceedings{VsquezVivar2005SuperoxideGF,
  title={Superoxide Generation from Nitric Oxide Synthase},
  author={Jeannette V{\'a}squez-Vivar and P Martasek and Balaraman Kalyanaraman},
  year={2005}
}
Application of the loop gap resonator technology and improvement in spin trapping methodologies have enormously increased our understanding of the mechanisms of superoxide formation from nitric oxide synthases. In this chapter we discuss the key role of cofactors such as tetrahydrobiopterin and protein-protein interactions in superoxide release from endothelial NOS. The pathophysiological effects of NOS-mediated superoxide generation in cardiovascular system are discussed. 

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