• Chemistry, Medicine
  • Published in
    Current opinion in…
    2002

Superoxide, superoxide dismutase and ischemic injury.

@article{Salvemini2002SuperoxideSD,
  title={Superoxide, superoxide dismutase and ischemic injury.},
  author={Daniela Salvemini and Salvatore Cuzzocrea},
  journal={Current opinion in investigational drugs},
  year={2002},
  volume={3 6},
  pages={
          886-95
        }
}
Oxidative stress results from an oxidant/antioxidant imbalance: an excess of oxidants relative to the antioxidant capacity. Recent evidence strongly suggests that oxidant stress plays a major role in several aspects of ischemia and reperfusion. Immunohistochemical and biochemical evidence demonstrate the significant role of reactive oxygen species, in particular superoxide and its reaction product peroxynitrite, formed by the interaction of superoxide and nitric oxide, in endothelial and tissue… CONTINUE READING

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