Superoxide, H2O2, and iron are required for TNF-alpha-induced MCP-1 gene expression in endothelial cells: role of Rac1 and NADPH oxidase.

@article{Chen2004SuperoxideHA,
  title={Superoxide, H2O2, and iron are required for TNF-alpha-induced MCP-1 gene expression in endothelial cells: role of Rac1 and NADPH oxidase.},
  author={Xi-Lin Chen and Qiang Zhang and Ruozhi Zhao and Russell M. Medford},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={286 3},
  pages={H1001-7}
}
Reactive oxygen species (ROS) play an important but not yet fully defined role in the expression of inflammatory genes such as monocyte chemoattractant protein (MCP)-1. We used complementary molecular and biochemical approaches to explore the roles of specific ROS and their molecular linkage to inflammatory signaling in endothelial cells. Adenovirus-mediated expression of superoxide dismutase and catalase inhibited TNF-alpha-induced MCP-1 gene expression, suggesting important roles of… CONTINUE READING

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