Supernatants from stored red blood cell (RBC) units, but not RBC-derived microvesicles, suppress monocyte function in vitro.

@article{Muszynski2015SupernatantsFS,
  title={Supernatants from stored red blood cell (RBC) units, but not RBC-derived microvesicles, suppress monocyte function in vitro.},
  author={Jennifer A Muszynski and Justin Bale and Jyotsna Nateri and Kathleen K. Nicol and Yijie Wang and Valerie P. Wright and Clay B. Marsh and Mikhail A Gavrilin and Anasuya Sarkar and Mark D Wewers and Mark W. Hall},
  journal={Transfusion},
  year={2015},
  volume={55 8},
  pages={
          1937-45
        }
}
BACKGROUND We have previously shown that critically ill children transfused with red blood cells (RBCs) of longer storage durations have more suppressed monocyte function after transfusion compared to children transfused with fresher RBCs and that older stored RBCs directly suppress monocyte function in vitro, through unknown mechanisms. We hypothesized that RBC-derived microvesicles (MVs) were responsible for monocyte suppression. STUDY DESIGN AND METHODS To determine the role of stored RBC… CONTINUE READING
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and immune function in critically ill children : a prospective observational study

  • JA Muszynski, R Nofziger, K Greathouse
  • 2015

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