Superiority of insulin analogues versus human insulin in the treatment of diabetes mellitus.

@article{Rossetti2008SuperiorityOI,
  title={Superiority of insulin analogues versus human insulin in the treatment of diabetes mellitus.},
  author={Paolo Rossetti and Francesca Porcellati and Carmine G. Fanelli and Gabriele Perriello and Elisabetta Torlone and Geremia B Bolli},
  journal={Archives of physiology and biochemistry},
  year={2008},
  volume={114 1},
  pages={3-10}
}
The modern goals of insulin replacement in Type 1 and Type 2 diabetes mellitus (T1, T2DM) are A1C <6.5% long-term, and prevention of hypoglycaemia (blood glucose, BG <70 mg/dl). In addition to appropriate education and motivation of diabetic subjects, the use of rapid- and long-acting insulin analogues, is critical to achieve these goals. The benefits of rapid-acting analogues (lispro, aspart and glulisine have similar pharmacodynamic effects) compared with non-modified human regular insulin… CONTINUE READING

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