Superiority of demeclocycline over lithium in the treatment of chronic syndrome of inappropriate secretion of antidiuretic hormone.

@article{Forrest1978SuperiorityOD,
  title={Superiority of demeclocycline over lithium in the treatment of chronic syndrome of inappropriate secretion of antidiuretic hormone.},
  author={John N. Forrest and Malcolm Cox and Chul Ki Hong and Gilmour Morrison and Marcin Bia and Igor Singer},
  journal={The New England journal of medicine},
  year={1978},
  volume={298 4},
  pages={173-7}
}
We evaluated demeclocycline and lithium therapy in 10 patients with the syndrome of inappropriate secretion of antidiuretic hormone. Despite severe water restriction, all patients had hyponatremia (mean +/- S.E.M. serum sodium of 122 +/- 1.1 meq per liter) and elevated urine osmolality (744 +/- 59 mOsm per kilogram) before treatment. Demeclocycline (600 to 1200 mg daily) restored serum sodium concentration to 139 +/- 1.1 meq per liter within five to 14 days, permitting unrestricted water intake… CONTINUE READING
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