Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist.

  title={Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist.},
  author={Hironori Yuyama and Yukiko Noguchi and Akira Fujimori and Masashi Ukai and Noriko Fujiyasu and Akiyoshi Ohtake and Shuichi Sato and Katsumi Sudoh and Masao Sasamata and K. Miyata},
  journal={European journal of pharmacology},
  volume={498 1-3},
The binding affinities of (E)-N-[6-methoxy-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-2-phenylethenesulfonamide monopotassium salt (YM598) for native human endothelin ETA and ETB receptors expressed in human coronary artery smooth muscle cells (CASMC) and a human melanoma cell line, SK-Mel-28, respectively, were examined, and the results compared with those for the endothelin receptor antagonists atrasentan and bosentan. The in vivo endothelin ETA receptor inhibitory activities of YM598 and… CONTINUE READING
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