Superior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hNEIL1.

@article{Krishnamurthy2008SuperiorRO,
  title={Superior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hNEIL1.},
  author={Nirmala Krishnamurthy and Xiaobei Zhao and Cynthia J Burrows and Sheila S David},
  journal={Biochemistry},
  year={2008},
  volume={47 27},
  pages={
          7137-46
        }
}
  • Nirmala Krishnamurthy, Xiaobei Zhao, +1 author Sheila S David
  • Published in Biochemistry 2008
  • Chemistry, Medicine
  • The DNA glycosylase hNEIL1 initiates the base excision repair (BER) of a diverse array of lesions, including ring-opened purines and saturated pyrimidines. Of these, the hydantoin lesions, guanidinohydantoin (Gh) and the two diastereomers of spiroiminodihydantoin (Sp1 and Sp2), have garnered much recent attention due to their unusual structures, high mutagenic potential, and detection in cells. In order to provide insight into the role of repair, the excision efficiency by hNEIL1 of these… CONTINUE READING

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